Team CLOT-LESS mission patch: a red blood vessel containing a fibrin clot, crossing a deep navy roundel marked University of British Columbia and CLOT-LESS, with a white maple leaf and stars.

CAN-RGX 2025–26 · Canadian Space Agency

An Analysis of Thrombolysis Kinetics in Microgravity

Team CLOT-LESS is developing an experimental platform to study thrombolysis and other hematologic research questions in zero gravity.

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CLOT-LESS team members in flight suits seated beside the experiment laptop inside the aircraft.

Our flight campaign

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  • 12

    Parabolas

    Across two flight days

  • 20 s

    Microgravity window

    Per parabola

  • 8

    Microfluidic channels

    4 drug, 4 saline control

  • 13.3 kg

    Payload mass

    70.5% margin

Project goals

  • Develop a testable platform for zero-g research

    Develop an experimental platform for testing thrombolysis and other hematologic research questions in zero gravity, with ground testing to support repeatable experiments.

  • Quantify microgravity effects on thrombolysis

    Measure the differential pressure change across a clot-containing microchannel during tenecteplase perfusion, in microgravity and at 1 g, over matched twenty-second analysis windows.

  • Validate system reliability

    Confirm that the integrated fluidic, sensing and logging system behaves consistently across repeated parabolas — to support repeatable hematologic experiments in reduced gravity.

  • Deliver scholarly and educational impact

    Translate the findings into peer-reviewed output and into classrooms — because a result that stays inside the team does not advance the field or the next generation working in it.

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The team

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